2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-138466
    Azido-PEG3-C6-Cl 1625717-44-3
    Azido-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C6-Cl
  • HY-134722
    Hydrazide-PEG4-Desthiobiotin
    Hydrazide-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydrazide-PEG4-Desthiobiotin
  • HY-140656A
    Biotin-PEG-Biotin 194920-55-3 99.32%
    Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin
  • HY-130537
    Azido-PEG6-alcohol 86770-69-6 98.0%
    Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-alcohol
  • HY-138524
    Thiol-PEG2-acid 1379649-73-6
    Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG2-acid
  • HY-140902A
    Biotin-PEG3-C3-NH2 183896-00-6
    Biotin-PEG3-C3-NH2 is a PEG-based PROTAC linker, with NH2 functional group, that can be used in the synthesis of PROTACs.
    Biotin-PEG3-C3-NH2
  • HY-140477
    Boc-NH-PEG6-CH2COOH 391684-36-9 98.0%
    Boc-NH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG6-CH2COOH
  • HY-134719
    ICG-Sulfo-OSu sodium 190714-28-4
    ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    ICG-Sulfo-OSu sodium
  • HY-140911
    Biotin-PEG6-azide 1085938-09-5 99.89%
    Biotin-PEG6-azide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG6-azide
  • HY-140476
    Boc-NH-PEG1-CH2COOH 142929-49-5 98.0%
    Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG1-CH2COOH
  • HY-130157
    3-(2-Pyridyldithio)propanoic Acid 68617-64-1 99.48%
    3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    3-(2-Pyridyldithio)propanoic Acid
  • HY-W045822
    Fmoc-Lys(Pal-Glu-OtBu)-OH 1491158-62-3 99.93%
    Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys(Pal-Glu-OtBu)-OH
  • HY-77959
    6-Maleimidocapronic acid 55750-53-3 98.0%
    6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    6-Maleimidocapronic acid
  • HY-W055861
    Fmoc-NH-PEG1-CH2COOH 260367-12-2 99.91%
    Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG1-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG1-CH2COOH
  • HY-108370
    N33-TEG-COOH 201467-81-4 98.0%
    N33-TEG-COOH (N3-TEG-COOH) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. N33-TEG-COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N33-TEG-COOH
  • HY-140890
    Biotin-PEG6-NHS ester 2055045-04-8 98.0%
    Biotin-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG6-NHS ester
  • HY-116069
    Propargyl-PEG1-NH2 122116-12-5 98.80%
    Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-NH2
  • HY-138734
    Propargyl-PEG2-NHS ester 2512228-06-5 ≥98.0%
    Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-NHS ester
  • HY-135912
    Biotin-PEG2-CH2CH2N3 945633-30-7 99.07%
    Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG2-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG2-CH2CH2N3
  • HY-133066
    m-PEG6-NHS ester 1449390-12-8
    m-PEG6-NHS ester is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG6-NHS ester
PROTAC Linkers Isoform Comparison

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