2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140459
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9 98.59%
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
  • HY-W096121
    PEG3 67439-82-1 ≥98.0%
    PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3
  • HY-126960
    Mal-PEG1-acid 760952-64-5 99.87%
    Mal-PEG1-acid is is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG1-acid
  • HY-126890
    Bis-PEG7-NHS ester 1334170-02-3 ≥98.0%
    Bis-PEG7-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG7-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG7-NHS ester
  • HY-W042625
    Hexaethylene glycol monomethyl ether 23601-40-3 98.77%
    Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hexaethylene glycol monomethyl ether
  • HY-140056
    Aminooxy-PEG1-propargyl 1895922-69-6
    Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Aminooxy-PEG1-propargyl
  • HY-133292
    Thiol-PEG4-alcohol 90952-27-5 99.39%
    Thiol-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG4-alcohol
  • HY-W001958
    Monomethyl octanoate 3946-32-5 ≥98.0%
    Monomethyl octanoate (Suberic acid monomethyl ester) is an ester product. Monomethyl octanoate is a PROTAC linker that can be used in the synthesis of PROTACs, DDD2 (HY-176261).
    Monomethyl octanoate
  • HY-W041970
    Ethyl 6-bromohexanoate 25542-62-5 99.93%
    Ethyl 6-bromohexanoate is a linker that can be used to synthesize PROTAC RSS0680 (HY-148062).
    Ethyl 6-bromohexanoate
  • HY-W009030
    N-Fmoc-8-aminooctanoic acid 126631-93-4
    N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    N-Fmoc-8-aminooctanoic acid
  • HY-150910
    Brigatinib C 1197958-75-0 99.72%
    Brigatinib C is a linker, as a part of PROTAC Linker to target HJM-561 (HY-156698).
    Brigatinib C
  • HY-135142
    Br-PEG3-OH 57641-67-5 98.81%
    Br-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Br-PEG3-OH
  • HY-138469
    NH2-PEG3-C6-Cl 1261350-60-0
    NH2-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C6-Cl
  • HY-130536
    Br-PEG4-CH2-Boc 1807505-29-8
    Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Br-PEG4-CH2-Boc
  • HY-130425
    Bromo-PEG1-acid 1393330-33-0 ≥98.0%
    Bromo-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bromo-PEG1-acid
  • HY-130541
    Propargyl-PEG2-OH 7218-43-1 99.66%
    Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Propargyl-PEG2-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-OH
  • HY-126942
    Amino-PEG6-alcohol 39160-70-8 99.85%
    Amino-PEG6-alcohol is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG6-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG6-alcohol
  • HY-124780
    HOOCCH2O-PEG4-CH2COOH 77855-75-5 ≥98.0%
    HOOCCH2O-PEG4-CH2COOH, compound 5, is a symmetric PEG linker, used for the synthesis of the first class of Homo-PROTAC.
    HOOCCH2O-PEG4-CH2COOH
  • HY-130161
    m-PEG4-Br 110429-45-3
    m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG4-Br
  • HY-128801
    NH2-PEG3-C1-Boc 189808-70-6 ≥98.0%
    NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    NH2-PEG3-C1-Boc
PROTAC Linkers Isoform Comparison

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